YBI's Portfolio Companies include those that are physically located at YBI as well as those that are either very early stage or are established operations that are seeking new market opportunities with information technology solutions. Physical Portfolio Companies that are in the incubating and commercialization stages are tenants of YBI's main facility. And unlike most incubators which "graduate" companies, YBI is commited to developing commercial properties for successful Portfolio Companies to "accelerate" their continued growth.

Virtual Portfolio Companies are generally very early stage ventures that can utilize the INSPIRE! flexible development suite and YBI's entrepreneurial resources while developing their technology and business plans. YBI also works close with a select number of established businesses that are innovative organizations integrating information technology applications into their businesses.