From Columbus:

Take I-71 N (102.1 miles); Merge onto I-76 E via EXIT 209 toward AKRON (60.3 miles); I-76 E becomes I-80 E (4.4 miles);  Merge onto I-680 S via EXIT 224B toward YOUNGSTOWN (5.1 miles); Take EXIT 5 toward GLENWOOD AVE/MAHONING AVE.; Turn RIGHT onto EDWARDS ST. ; Turn RIGHT onto MAHONING AVE; Turn RIGHT onto FEDERAL PLAZA WEST.

From Cleveland:

Take I-80 E toward YOUNGSTOWN (Portions toll). (50.7 miles); Merge onto I-680 S via EXIT 224B toward YOUNGSTOWN (5.1 miles); Take EXIT 5 toward GLENWOOD AVE/MAHONING AVE.; Turn RIGHT onto EDWARDS ST. ; Turn RIGHT onto MAHONING AVE; Turn RIGHT onto FEDERAL PLAZA WEST.

From Pittsburgh:

Take  I-76 W via EXIT 77 toward YOUNGSTOWN OHIO (Portions toll) (36.2 miles); Merge onto I-680 N via EXIT 234/16A toward YOUNGSTOWN (Portions toll) (11.4 miles); Take EXIT 5 toward GLENWOOD AVE/MAHONING AVE.; Turn RIGHT onto EDWARDS ST. ; Turn RIGHT onto MAHONING AVE; Turn RIGHT onto FEDERAL PLAZA WEST.

Landmarks close by include the Home Savings and Loan building (with the clock tower) and the George V. Voinovich Government Center (directly across the street).

On street parking is available.